Release date: 2012-10-22 Recently, researchers at the Salk Institute for Biological Studies in the United States found that a small molecule protein E4-ORF3 produced by cold virus can destroy organelles associated with growth, replication, and cancer. This protein forms a three-dimensional network in the nucleus that captures the target organelle. This discovery opens up a new path for the treatment of cancer, published in the October 11 issue of Cell. E4-ORF3 is an oncogenic protein encoded by adenovirus that blocks the binding of the tumor suppressor protein p53 to its target gene. P53 is considered to be a guardian of the genome, which normally inhibits tumorigenesis by self-destruction of cells that damage DNA. In almost all types of human cancers, the tumor suppressive effect of p53 is lost, allowing cancer cells to escape normal growth control. E4-ORF3 inhibits p53, allowing adenoviruses to replicate in infected human cells. Research leader Clodagh O'Shea said that cancer is a black box, and the interaction between the small DNA tumor virus protein and the tumor suppressor complexes can be found to find the key to the black box. But if we don't know the structure of this protein, we can't understand why it can outperform the tumor suppressor gene. Two years ago, O'Shea discovered that E4-ORF3 paves the way for the proliferation of adenoviruses by inhibiting genes that help cells fight the virus. E4-ORF3 can self-assemble in a cell, called a disordered, reticular structure, which in turn captures and inactivates tumor suppressor proteins. In addition, the researchers analyzed the ultrastructure of the polymer formed by E4-ORF3 in the nucleus. The research will help scientists develop new small molecule drugs that work by binding and disrupting cellular components that help cancer cells grow and spread. To avoid killing healthy cells, a "tumor-busting virus" is designed, which can only destroy cancer cells because it can only replicate in p53-inhibited cancer cells. When a cancer cell is killed, it releases the replicated virus and then looks for and kills cancer cells that spread throughout the body. Designing this virus requires E4-ORF3 to lose the role of p53 in inactivating normal cells, otherwise E4-ORF3 kills normal cells while killing cancer cells. Source: Bio Valley Skin Care Product,Led Light Therapy,Blackhead Remover Tool,Silicone Facial Cleanser Brush Shenzhen Jie Zhong Lian Investment Co., Ltd. , https://www.szmeizon.com