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Generally speaking, the particles prepared by wet mixing granulation are irregular in shape, uniform in particle size distribution, and the structure is better than other conventional granulation processes, but the granulated finished product involves many factors, and its influence is now Brief description.
1. The influence of the rotation speed of the stirring paddle and the cutting blade can be said that the size and distribution of the particle size are directly related to the rotation speed of the stirring paddle and the cutting blade. When the rotation speed of the cutting blade is slow, the particle size becomes larger, and the particle size becomes larger when the rotation speed is faster. Small; when the stirring paddle speed is slow, the particle size is small, and the particle speed is large as the speed is fast, and the two functions are opposite.
2, the impact of mixing, granulation process and time. In the operation of the high-speed mixing granulator, the rotation of the stirring paddle causes the material in the pot to roll to the space, so that the material of the bottom of the pot is thrown along the wall of the pot, this action is connected one after another. The soft material is pushed to the fast cutting knife and cut into particles of different sizes, and the particles are rounded and gradually become spherical as the particles roll over each other for a while. It can be seen from the above that the speed and time of the stirring paddle and the cutting blade affect the particle size of the granulation.
3. Influence of materials and concentration In the wet mixed granulation production, alcohol granules or dextrin binders are commonly used for granulation, and the stickiness of the two is determined to be different. It is common to use alcohol to make granules. The granules are small and fine, and easy to dry. This is because alcohol does not have viscosity, and it has a loose effect. It is ideal for granulation of Chinese medicine with high viscosity. When the paste is used to refine the granules, the granules produced are large and coarse, and the drying is slow. This is because the dextrin is sticky and has a polymerization effect, and the medicinal preparation having no viscosity is preferred.
In addition, whether it is diluted with concentrated extract as a material or a material using dextrin or other binder, when producing smaller particles, the slurry concentration of the material can be thinner. When larger particles are required, the material is The slurry concentration can be slightly stronger.
What factors affect the high-speed mixing granulation mechanism?
Factors affecting the high-speed mixing granulation mechanism of finished products: