What factors should be considered by the pharmaceutical factory for the selection of tablet presses?

What factors should be considered by the pharmaceutical factory for the selection of the tablet presses: (1) the grades and added value of the products produced. If the tablet press manufacturer produces a good variety of products and has a high added value, it can use high-grade equipment. After all, such equipment has good performance and high degree of automation, which can ensure the quality of the products;

(2) Economic affordability. The tablet press manufacturers generally have joint ventures and imported presses with certain advantages in the application of advanced technology, equipment stability, process control and the guarantee of the quality of the final product, but the price is 5~ 6 times or even higher, depending on the economic affordability of the equipment manufacturer; (3) the size of the shift. In the selection of equipment, it is not necessary to blindly pursue the output of a single machine, but to determine the stand-alone output of the required equipment according to the actual production demand;

(3) The floor space of the workshop. If the floor plan of the workshop is relatively large in area, the medium and low speed tablet press can be selected, and the number of equipment of the tablet press manufacturer can be appropriately increased, so that the input of the equipment can be reduced. If the equipment layout of the workshop is tight, a sub-high speed or high speed tablet press can be used, which, despite the high investment, avoids the difficulty in equipment layout. However, regardless of the large or small area, the tablet press manufacturer believes that it is advisable to arrange at least two tablet presses under normal circumstances. This avoids the production line downtime when the tablet press fails.

In recent years, many tablet manufacturers have gradually approved high-speed rotary tablet presses from trial use, and currently have the potential to replace high-speed rotary tablet presses. Exploring the reason, I believe that people who have a general understanding of high-speed rotary tablet presses will say that "the advantage is that the film is small, efficient, energy-saving, land-saving, and highly informative." Taking our high-speed rotary tablet press as an example, the tablet press manufacturers provide a summary analysis of the cost performance from six aspects, for reference when using the user.

(1) High output output. The tablet press with the same tablet diameter and similar die number, the output of the high-speed rotary tablet press is 4 to 5 times that of the low-speed rotary tablet press. That is to say, the same output is completed in the same time, which is the relationship between the high-speed rotary tablet press and 4 to 5 low-speed rotary tablet presses.

(2) High product yield. We know that the material loss in the tablet production process is mainly concentrated in the initial stage of parameter setting and adjustment of the test piece and the load shedding protection before shutdown. For the normal production of high-speed rotary tablet presses, the batch utilization rate is above 99%; while the low-speed rotary tablet presses are difficult to achieve this index, especially when multiple devices are selected, the chances of wasting materials will be counted. Double or double.

(3) The direct cost of equipment is basically the same. The price of a domestic high-speed rotary tablet press may be able to buy 4 to 5 low-speed rotary tablet presses, but the low-speed rotary tablet press must be equipped with multiple sets of auxiliary equipment, and the comprehensive calculation will be similar.

(4) Energy saving and consumption reduction are significant. A high-speed rotary tablet press requires a cleaning workshop of approximately 20 m2, while a low-speed rotary tablet press requires a total of 40 to 60 m2. Due to the increased area of ​​the purification area, the amount of purified air required for the production process is also proportionally increased, such as the 3.5m indoor height and the production of 8h/d, the ventilation is 15 times/h, the high-speed rotary tablet press and the low-speed rotary type. The amount of purified air required by the tablet press is 8400 m3 and 16800-25200 m3, respectively. Over time, the cost difference can not be underestimated. In addition, in the process of tableting, in addition to the main machine of the tablet press, each main machine needs to be equipped with auxiliary equipment such as lifting feeder, vacuum cleaner, sieve machine and metal detector. Therefore, the overall energy consumption is the same as the purification system, and it is also an amazing number.

(5) Labor costs are greatly reduced. Domestic pharmaceutical companies generally allocate one to two operators for each tablet press. For high-speed rotary tablet presses, even with the automatic control of tablet quality, you can even operate multiple devices for one person.

(6) Equipment management costs have been greatly reduced. Daily cleaning and maintenance of the tablet press is essential. In addition to labor costs, a large number of consumables are required, including drinking water, purified water, cleaning agents, disinfectants, and anti-rust oils for protecting the die. Obviously, the advantages of a set of equipment compared to multiple sets of equipment are self-evident.

Of course, there are still some shortcomings in choosing a high-speed rotary tablet press – facing the risk of production schedule. Once a sudden failure to stop production, the impact on production is huge; while the low-speed machine with relatively low production is much less risky.

Therefore, the tablet press manufacturer must select the type from the actual needs of the pharmaceutical company, but also focus on the high-speed machine's functional integrity, operational stability, safety and reliability, laboratory tablet press operation cleaning and maintenance convenience. And comprehensive balance of service and timeliness.

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