The clearest telomerase structure to date has taken an important step toward the development of new therapies such as cancer. April 27, 2018 Source: Science and Technology Daily According to a paper published by the British journal Nature on the 25th, the team of American scientists used cryo-electron microscopy to determine the structure of telomerase at the highest resolution to date. Given the close relationship between telomerase and cancer and aging, this finding represents an important step toward the development of telomerase-related therapies. To this day, scientists are not fully sure of the real cause of aging and cancer, and the discovery of telomere function is thought to open up a new anti-aging and cancer treatment. Telomeres are the "hat" structure at the end of the chromosome, similar to the plastic tip on the shoelace, which protects against chromosome "wear". Every time the cell divides, the telomeres become shorter until the cells stop dividing and die. Telomerase can avoid this by adding DNA to the ends of the chromosome. The academic community believes that the rational use of biological telomerase technology will uncover the mysteries of serious diseases such as human aging and cancer. The resolving power of electron microscopy in the past can show the details of the microscopic world, but since biological samples cannot withstand the radiation damage of electron beams, it has been difficult to obtain high-resolution information about biological samples. Catherine Collins, a researcher at the University of California, Berkeley, and colleagues decided to use the newer technology to "uncover" telomerase. The combination of cryo-electron microscopy technology and the resolution revolution in recent years is considered to open a new era in the analysis of biomolecular structures. Several pioneers of this technology were awarded the 2017 Nobel Prize in Chemistry. The research team used the cryo-electron microscopy technique to determine the structure of human telomerase, which is the highest resolution telomerase image obtained by humans. In the news and opinion articles accompanying the paper, Michael Stone, a scientist at the University of California, Santa Cruz, said that the lack of telomerase structure data hindered the clinical regulation of telomerase progression, but now researchers are finally An image of the molecule combined with its substrate is obtained on the sub-nanometer scale. Editor-in-Chief <br> In the long river of life science discovery, "black box" is opening to people one by one. The mysterious telomere is related to the lifespan and death of the cell - when the telomere becomes shorter, the cell ages; conversely, if the telomerase activity is high, the telomere length can be maintained and the aging of the cell is delayed. Therefore, scientists believe that telomere is an extremely important piece in the huge puzzles of human-related puzzles. The complete disclosure of telomerase structure will help reverse aging and turn cancer into a treatable Form of disease. (Technology Daily Beijing April 26th reporter Zhang Mengran) 1, Material: made of medical grade polypropyle(PP) and PS.
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