USP Top Quality 99% API Crizotinib CAS 877399-52-5 for Anti-Cancer

November 05, 2018

  • Model NO.: 877399-52-5
  • Customized: Non-Customized
  • Suitable for: Elderly, Children, Adult
  • Purity: >99%
  • MW: 450.343
  • Deliver Time: About 5 Days
  • Trademark: LSW
  • Specification: SGS GMP
  • HS Code: 3004390090
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Mf: C21h22cl2fn5o
  • MOQ: 10 Grams
  • Deliver Methods: by Express
  • Transport Package: 25kg/Bag or as Required
  • Origin: China
USP Top Quality 99% API Crizotinib CAS 877399-52-5 for Anti-cancer

1. Quick Details:
 
Product name: Crizotinib
CAS: 877399-52-5
MF: C21H22Cl2FN5O
MW: 450.343
Purity: 99% min
Appearance: White Crystalline Powder
MOQ:  10 grams
Storage: Store in a cool, dry place
Deliver time: About 5 days 
Deliver methods: By express (door to door)

2. What is Crizotinib:

Crizotinib (trade name Xalkori,) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy inanaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

3. How does Crizotinib works:

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK ('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger non-smokers who do not have mutations in either theepidermal growth factor receptor gene (EGFR) or in the K-Ras gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.

4. Crizotinib is used for:

Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.

Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.

Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.

Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

5. Do NOT use crizotinib if:

you are allergic to any ingredient in crizotinib
you have previously developed a certain lung problem (pneumonitis) from taking crizotinib
you have a history of certain types of irregular heartbeat (eg, QT prolongation, long QT syndrome)
 
Contact your doctor or health care provider right away if any of these apply to you.

6. COA:
 
 Test Items  Specification  Results
 Description  White to off white crystalline powder  Comply
 Melting point  166-170ºC  167.3-168.1ºC
 Identification  Positive reaction  Positive reaction
 Related substances  <1.0%  0.16%
 Loss on drying  <0.5%  0.06%
 Residue on ignition  <0.1%  0.02%
 Chloride  <0.014%  <0.014
 Heavy Metals  <20ppm  <20ppm
 Clarity of solution  Conform to standard  Complies
 Microbial Limit  <20ppm  <20ppm
 Assay  >99.0%  99.12%
 
7. Our Adwantage: 

   High quality with competitive price: 
   1) Standard: Enterprise Standard
   2) All Purity:>=99%
   3) We are manufacturer and can provide high quality products with factory price. 

   Fast and safe delivery:
   1) Parcel can be sent out in 24 hours after payment. Tracking number available
   2) Secure and discreet shipment. Various transportation methods for your choice. 
   3) Customs pass rate: >=99%
   4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 

   We have clients throughout the world: 
   1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
   2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
   3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

   Everybody is talking the similar words, what I want to say is: Just give me a chance, Just have a try on me, maybe you will get a surprise from me!  


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