The Hefei Institute of Material Science of the Chinese Academy of Sciences has learned that researchers at the Institute have made significant progress in the study of glioma microenvironment - the study found that "CCL20 promotes cell invasion and recurrence of glioma in hypoxic glioma tissues" That is, the cytokine CCL20 accelerates the recurrence of glioma in the state of "anoxia" or "oxygen deficiency". CCL20 is one of the important members of the chemokine family. It is a cytokine that promotes tumor malignancy and causes chemotherapy resistance and recurrence of tumors, which is not conducive to the prognosis of cancer patients. Related results have recently been published in the famous international oncology academic journal "Oncotarget". Gliomas are common primary tumors of the central nervous system with an incidence of about 100,000. The microenvironment of the glioma tissue region is composed of tumor cells, immune cells and various factors secreted by the tumor cells, among which various factors secreted by tumor cells or immune cells, such as growth factors, chemokines, and pro-inflammatory factors. And anti-inflammatory factors constitute a micro-environment network, they interact, and jointly regulate and affect the progress of the tumor. Melatonin is an amine hormone produced by the pineal gland of mammals and humans. It enters the brain through the blood-brain barrier and easily enters cells through the cell membrane. In recent years, studies have shown that melatonin has anti-tumor and improved tumor-bearing living environment and is recommended as one of the adjuvant treatments for tumors. In view of this, Fang Zhiyou, a researcher at the Medical Physics Center of the hospital, and Dr. Chen Xueqi, used glioma cells and in situ glioma nude mice as models to analyze the role of CCL20 in the progression of malignant glioma and melatonin. Antagonistic mechanism, establishing a regulatory network of chemokines and physiological hormones in the recurrence and malignant development of glioma, in order to provide new clues and clinical theoretical basis for the treatment of glioma. Studies have shown that CCL20 promotes cell invasion and recurrence of glioma in hypoxic glioma tissues. Further studies have shown that melatonin can inhibit the activation of CCL20 by regulating part of the signaling, thereby improving the living environment of the tumor. These findings provide new directions and visual perspectives for re-recognizing the microenvironment and malignant progression of gliomas and clinical cancer treatment. According to reports, in addition to the tumor microenvironment (mainly referred to as CCL20), the research team will also find chemotherapy resistance and tumor recurrence of glioma. It has also been found that gene mutations (mainly p53) will have similar "side effects". Source: China News Network Adult Wet Wipes are disposable, pre-moistened wipes designed for
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