Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib

October 25, 2018

Model NO.: PF-06463922
Mf: C21h19fn6o2
MW: 406.41
CAS: 1454846-35-5
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Model NO.: PF-06463922
Mf: C21h19fn6o2
MW: 406.41
CAS: 1454846-35-5
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

PF06463922 Basic Info.

Synonyms: (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
CAS1454846-35-5, 
MF:C21H19FN6O2
MW:406.41
PF-06463922 is a novel, orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib

Usage:PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.

PF-06463922 Application:

▪  PF-06463922 is the second generation of crizotinib,in total ALK inhibitors Divided into the third generation.
▪  The ALK Drug programs is crizotinib→AP26113,CH5424802,LDK378→PF06463922.

▪  The efficacy of PF-06463922 is crizotinib forty times,AP26113 six times.
 PF-06463922 can inhibit 9 mutation after resistant of crizotinib,AP26113 can inhibit two kinds,CH5424802  can inhibit three kinds,LDK378can inhibit four kinds,but AP26113 and LDK378 just like sister,as they have almost the same structure, mechanism of action.

▪  3922 using new big ring structure, action mechanism and the effect is greatly increased.

▪   PF-06463922 also can inhibition of ros1 targets.Its force is 3 times of alk, is currently ros1 second generation of medicine.

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

Wuhan Demeikai Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib


Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

The list of cortical hormone drugs is as follows:
Name standard CAS
Prednisolon Acetate Usp32 /ep6 52-21-1
Prednisolon Base Bp2010/Usp32/Ep7 50-24-8
Prednison Usp32 1953/3/2
Prednison Acetate Cp2005 125-10-0
Betamethasone Base Ep6 378-44-9
Betamethaasone Usp32 5593-20-4
Dipropionate    
     
Clobetasol Propionate Usp34 25122-46-7
Cortisone Acetate enterprise standard 1950/4/4
     
Dexamethasone Sodium Phosphate EP6 2392-39-4
     
Fluocinolone Acetonide Usp32 67-73-2
Fluocinonide Usp32/CP 356-12-7
Hydrocortisone Ep7 50-23-7
     
Hydrocortisone Acetate Ep7 1950/3/3
Dexamethasone Acetate EP6 1177-87-3
Triamcinol0ne acetonide acetate enterprise standard 3870/7/3
Triamcinol0n Acetonide BP/USP/EP 76-25-5
Triamcinol0ne Base BP/USP/EP 124-94-7
Halcinonide Cp2005 3093-35-4
16α-Hydroxy-Prednisolone enterprise standard 13951-70-7


Reason to choose us 

.Guarantee the quality of products ,our Pharmaceutical Intermediate purity≥99% .

.Variety diversification & Adequate stock make sure we could meet your require

.Professional service and rich experience ,we also could give you some advise about 
please feel free to contact us if you have any question.

Payment Term:T/T  , Moneygram , Western Union.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib
Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 
  Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

PF06463922 Basic Info.

Synonyms: (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
CAS1454846-35-5, 
MF:C21H19FN6O2
MW:406.41
PF-06463922 is a novel, orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib

Usage:PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.

PF-06463922 Application:

▪  PF-06463922 is the second generation of crizotinib,in total ALK inhibitors Divided into the third generation.
▪  The ALK Drug programs is crizotinib→AP26113,CH5424802,LDK378→PF06463922.

▪  The efficacy of PF-06463922 is crizotinib forty times,AP26113 six times.
 PF-06463922 can inhibit 9 mutation after resistant of crizotinib,AP26113 can inhibit two kinds,CH5424802  can inhibit three kinds,LDK378can inhibit four kinds,but AP26113 and LDK378 just like sister,as they have almost the same structure, mechanism of action.

▪  3922 using new big ring structure, action mechanism and the effect is greatly increased.

▪   PF-06463922 also can inhibition of ros1 targets.Its force is 3 times of alk, is currently ros1 second generation of medicine.

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

Wuhan Demeikai Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib


Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 

The list of cortical hormone drugs is as follows:
Name standard CAS
Prednisolon Acetate Usp32 /ep6 52-21-1
Prednisolon Base Bp2010/Usp32/Ep7 50-24-8
Prednison Usp32 1953/3/2
Prednison Acetate Cp2005 125-10-0
Betamethasone Base Ep6 378-44-9
Betamethaasone Usp32 5593-20-4
Dipropionate    
     
Clobetasol Propionate Usp34 25122-46-7
Cortisone Acetate enterprise standard 1950/4/4
     
Dexamethasone Sodium Phosphate EP6 2392-39-4
     
Fluocinolone Acetonide Usp32 67-73-2
Fluocinonide Usp32/CP 356-12-7
Hydrocortisone Ep7 50-23-7
     
Hydrocortisone Acetate Ep7 1950/3/3
Dexamethasone Acetate EP6 1177-87-3
Triamcinol0ne acetonide acetate enterprise standard 3870/7/3
Triamcinol0n Acetonide BP/USP/EP 76-25-5
Triamcinol0ne Base BP/USP/EP 124-94-7
Halcinonide Cp2005 3093-35-4
16α-Hydroxy-Prednisolone enterprise standard 13951-70-7


Reason to choose us 

.Guarantee the quality of products ,our Pharmaceutical Intermediate purity≥99% .

.Variety diversification & Adequate stock make sure we could meet your require

.Professional service and rich experience ,we also could give you some advise about 
please feel free to contact us if you have any question.

Payment Term:T/T  , Moneygram , Western Union.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib
Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib

Best Quality Good Price PF-06463922 Powder Second Generation of Crizotinib 
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