High Quality Pharmaceutical Chemicals Gefitinib for Sale

October 31, 2018

Model NO.: 184475-35-2
Delivery: 3-5 Days 100% Door to Door
Sample: Free
Shipment: EMS, FedEx, TNT, DHL, UPS
Payment: Western Union, Moneygram, T/T, Bitcion
Name: Gefitinib
CAS: 184475-35-2
Trademark: Shuou
Transport Package: Discreet Ways of Packing for Customs Pass Guarante
Specification: Building Muscle, Burning Fat and Gaining Strength
Origin: China
HS Code: 293729002
Model NO.: 184475-35-2
Delivery: 3-5 Days 100% Door to Door
Sample: Free
Shipment: EMS, FedEx, TNT, DHL, UPS
Payment: Western Union, Moneygram, T/T, Bitcion
Name: Gefitinib
CAS: 184475-35-2
Trademark: Shuou
Transport Package: Discreet Ways of Packing for Customs Pass Guarante
Specification: Building Muscle, Burning Fat and Gaining Strength
Origin: China
HS Code: 293729002
COA:
 
Product name  
Gefitinib
 
CAS No.  
184475-35-2		 Outer Packing  
1KG
 
Production date  
May,05,2016		 Shelf life  
May.04,2019
Standard adopted  
 
house standard
Items of analysis Specification Results
 
 
Appearance		  
 
White to off-white powder		  
 
off-White powder
 
 
Identifcation		  
 
HPLC(RT)		  
 
Complies
 
 
Loss on drying		  
 
≤ 0.5%		  
 
0.13%
 
 
Residue on ignition		  
 
≤0.,1%		  
 
0.1%
 
 
Max Single Impurity		  
 
≤ 0.10 %		  
 
0.09%
 
 
Total Impurity		  
 
≤.1.0%		  
 
0.24%
 
 
Purity(HPLC)		  
 
≥99%		  
 
99.76%
Conclusion Qualified

Mechanism of action:

Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.

How to use Gefitinib Tablet:

Take gefitinib by mouth once daily, with or without food, or as directed.

Medications which reduce or completely block stomach acid (e.g., proton pump inhibitors/PPIs, H2 blockers, antacids) may decrease the absorption of gefitinib. This could decrease the effectiveness of gefitinib. Consult your doctor or pharmacist if you are taking any of these medications.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day...

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Our Advantage
 
Best Quality Professional leading manufacturers in China.Strict
quality control before products are allowed to sell.
Competitive Price Factory direct sales.Best prices you're sure to be
satisfied.
Safe Packing Professional packing department which have more
than 16 years experience in disguising packages
Fast Delivery Plenty in stock,delivery within 24 hours after the
payment.Fast and secure delivery by DHL, TNT,
FedEx, HKEMS, UPS, etc.
Payment T/T,Western Union,Money Gram,Bitcoin.
Service Photos of parcel and tracking number offered
timely;24/7 online helpful service
Discount Specials are possible when client's order is big
enough, including the discount policy

High Quality Pharmaceutical Chemicals Gefitinib for Sale
High Quality Pharmaceutical Chemicals Gefitinib for Sale

  COA:
 
Product name  
Gefitinib
 
CAS No.  
184475-35-2		 Outer Packing  
1KG
 
Production date  
May,05,2016		 Shelf life  
May.04,2019
Standard adopted  
 
house standard
Items of analysis Specification Results
 
 
Appearance		  
 
White to off-white powder		  
 
off-White powder
 
 
Identifcation		  
 
HPLC(RT)		  
 
Complies
 
 
Loss on drying		  
 
≤ 0.5%		  
 
0.13%
 
 
Residue on ignition		  
 
≤0.,1%		  
 
0.1%
 
 
Max Single Impurity		  
 
≤ 0.10 %		  
 
0.09%
 
 
Total Impurity		  
 
≤.1.0%		  
 
0.24%
 
 
Purity(HPLC)		  
 
≥99%		  
 
99.76%
Conclusion Qualified

Mechanism of action:

Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.

How to use Gefitinib Tablet:

Take gefitinib by mouth once daily, with or without food, or as directed.

Medications which reduce or completely block stomach acid (e.g., proton pump inhibitors/PPIs, H2 blockers, antacids) may decrease the absorption of gefitinib. This could decrease the effectiveness of gefitinib. Consult your doctor or pharmacist if you are taking any of these medications.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day...

Hot sale products: 
 
Weight Loss Powder:
 

L(-)-Carnitine
CAS:541-15-1

Rimonabant
CAS:158681-13-1

Orlistat
CAS: 96829-58-2

Levothyroxine Sodium(T4)
CAS: 25416-65-3

 
CAS: 125-69-9

Lorcaserin hydrochloride
CAS:846589-98-8

Zopiclone
CAS:43200-80-2

Synephrine
CAS:5985-28-4

Calcium pyruvate
CAS:52009-14-0

Hydroxycitric acid
CAS:6205-14-7

Picolinic acid chromium(III) salt
CAS:14639-25-9

Theobromine
CAS:83-67-0

5-Hydroxytryptophan
CAS:4350-09-8

Kidney Bean Extract
CAS:85085-22-9

L-Triiodothyronine(T3)
CAS:55-06-1

Antineoplastic Powder:
 

Letrozol.
 

Anastrozol.(Arimidex)
CAS:120511-73-1

L-Triiodothyronine(T3)
CAS:55-06-1

Trilostan.
CAS:13647-35-3

Formestan.
CAS:566-48-3

 
CAS:107868-30-4

Estrogen Hormone/Estrogen-blocking Powder:
 

 
CAS:54965-24-1

Clomiphene Citrate(Clomid)
 

Progesterone
CAS: 57-83-0

Estradiol
CAS: 50-28-2

Estradiol valerate
CAS: 979-32-8

Diethylstilbestrol
CAS: 56-53-1

Hexestrol
CAS:84-16-2

Surface Anesthesia Powder:
 

Benzocaine
CAS:94-09-7

Tetracaine Hydrochloride
CAS:136-47-0

Procaine Hydrochloride
CAS:51-05-8

Lidocaine Hydrochloride
CAS:6108-05-0

Lidocaine Base
CAS:137-58-6

Aarticaine Hydrochloride
CAS:23964-57-0

Dyclonine Hydrochloride
CAS:536-43-6

Levobupivacaine Hydrochloride
CAS:27262-48-2

Propitocaine hydrochloride
CAS:1786-81-8

Ropivacaine Mesylate
CAS:854056-07-8

Tetracaine Hydrochloride
CAS:136-47-0

Our Advantage
 
Best Quality Professional leading manufacturers in China.Strict
quality control before products are allowed to sell.
Competitive Price Factory direct sales.Best prices you're sure to be
satisfied.
Safe Packing Professional packing department which have more
than 16 years experience in disguising packages
Fast Delivery Plenty in stock,delivery within 24 hours after the
payment.Fast and secure delivery by DHL, TNT,
FedEx, HKEMS, UPS, etc.
Payment T/T,Western Union,Money Gram,Bitcoin.
Service Photos of parcel and tracking number offered
timely;24/7 online helpful service
Discount Specials are possible when client's order is big
enough, including the discount policy

High Quality Pharmaceutical Chemicals Gefitinib for Sale
High Quality Pharmaceutical Chemicals Gefitinib for Sale

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