Kinase Inhibitors Afatinib 439081-18-2 Gilotrif for Lung Cancer Treatment

October 31, 2018

Model NO.: 439081-18-2
Quality Standard: Bp, USP, Ep, Cp
Usage: Treating Cancer
Appearence: Powder
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Mf: C24h25clfn5o3
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei
Model NO.: 439081-18-2
Quality Standard: Bp, USP, Ep, Cp
Usage: Treating Cancer
Appearence: Powder
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Mf: C24h25clfn5o3
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei

Product Description

USP Kinase Inhibitors Afatinib 439081-18-2 Gilotrif for Lung Cancer Treatment 

1. Quick Details:
 

Product name: Afatinib (BIBW 2992);Gilotrif
Synonyms: BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
CAS: 439081-18-2
MF: C24H25ClFN5O3
MW: 485.944
Purity: 99.5% min 
Appearance: White or Nearly White Crystalline Powder
MOQ: 10G
Specifications: Pharmaceutical Grade
Deliver time: About 5 days
Deliver methods: TNT,EMS,HKEMS,DHL,ect.(door to door)

2. What is Afatinib ?

Afatinib is pronounced aff-a-tin-ib. It has the brand name Giotrif (jee-oh-triff). It is a type of biological therapy called a tyrosine kinase inhibitor (TKI). It is a treatment for non small cell lung cancer that has spread outside the lung or to other parts of the body.

It has received regulatory approval for use as a treatment for non-small cell lung cancer,although there is emerging evidence to support its use in other cancers such as breast cancer.

3. How afatinib works:

This type of drug works by blocking particular proteins on cancer cells that encourage the cancer to grow. Afatinib blocks proteins called epidermal growth factor receptors (EGFR). Cancers that have these receptors are called EGFR positive.

Between 10 and 15 people out of every 100 with non small cell lung cancer (10 to 15%) have EGFR positive cancer. Doctors check your cancer cells to see if they have the receptors before you have this treatment.

Afatinib may shrink the cancer or stop it growing for a time

4. Uses and fuction:

Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal growth factor receptor-EGFR) in some tumors.

5. Mechanism of action:

Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation tyrosine-kinase inhibitors (TKIs) likeerlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.

6. COA:
 
Item Requirements Test Results
Description Off-white powder Off-white powder
Identification HPLC ,NMR Complies
Residue on Ignition ≤0.10% 0.05%
Loss on Drying ≤0.50% 0.15%
Heavy Metal ≤20ppm <20ppm
Purity(HPLC) ≥99.0% 99.99%
Conclusion It complies with EnterpriseStandard
 

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Peptide List
 
Product Name Specification
ACE 031 1 mg/vial, 10 vials/kit
Follistatin 315 1 mg/vial, 10 vials/kit
Follistatin 344 1 mg/vial, 10 vials/kit
***************************** *****************************
MGF 2 mg/vial, 10 vials/kit
PEG - MGF 2 mg/vial, 10 vials/kit
DSIP 2 mg/vial, 10 vials/kit
TB500 2 mg/vial, 10 vials/kit
Oxytocin 2 mg/vial, 10 vials/kit
Hexarelin 2 mg/vial, 10 vials/kit
Triptorelin 2 mg/vial, 10 vials/kit
Ipamorelin 2 mg/vial, 10 vials/kit
Sermorelin 2 mg/vial, 10 vials/kit
Gonadorelin 2 mg/vial, 10 vials/kit
Tesamorelin 2 mg/vial, 10 vials/kit
BPC 157 2 mg/vial, 10 vials/kit
AOD-9604 2 mg/vial, 10 vials/kit
H 176-191 2 mg/vial, 10 vials/kit
CJC-1295 2 mg/vial, 10 vials/kit
CJC-1295 DAC 2 mg/vial, 10 vials/kit
***************************** *****************************
GHRP-2 5 mg/vial, 10 vials/kit
GHRP-6 5 mg/vial, 10 vials/kit
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