CAS No.: 877399-52-5 Purity 99% Crizotinib for Anti-Cancer

October 30, 2018

Model NO.: 877399-52-5
Delivery Time: Shipped in 3 Days After Payment
Payment Method: T/T, Western Union, Money Gram, Paypal
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Usage: Treating Cancer
Appearence: White Solid
Mf: C21h22cl2fn5o
Quality Standard: Bp, USP, Ep, Cp
Trademark: Disel
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei
HS Code: 2942000000
Model NO.: 877399-52-5
Delivery Time: Shipped in 3 Days After Payment
Payment Method: T/T, Western Union, Money Gram, Paypal
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Usage: Treating Cancer
Appearence: White Solid
Mf: C21h22cl2fn5o
Quality Standard: Bp, USP, Ep, Cp
Trademark: Disel
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei
HS Code: 2942000000

Quick Details:
 

Product name: Crizotinib
CAS: 877399-52-5
MF: C21H22Cl2FN5O
MW: 450.343
Purity: 99% min
Appearance: White Crystalline Powder
MOQ:  10 grams
Storage: Store in a cool, dry place
Deliver time: About 5 days 
Deliver methods: By express (door to door)

What is Crizotinib:

Crizotinib (trade name Xalkori,) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy inanaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

How does Crizotinib works:

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK ('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger non-smokers who do not have mutations in either theepidermal growth factor receptor gene (EGFR) or in the K-Ras gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.

Crizotinib is used for:

Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.

Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.

Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.

Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

Do NOT use crizotinib if:

you are allergic to any ingredient in crizotinib
you have previously developed a certain lung problem (pneumonitis) from taking crizotinib
you have a history of certain types of irregular heartbeat (eg, QT prolongation, long QT syndrome)
 
Contact your doctor or health care provider right away if any of these apply to you.

COA:
 
 Test Items  Specification  Results
 Description  White to off white crystalline powder  Comply
 Melting point  166-170ºC  167.3-168.1ºC
 Identification  Positive reaction  Positive reaction
 Related substances  <1.0%  0.16%
 Loss on drying  <0.5%  0.06%
 Residue on ignition  <0.1%  0.02%
 Chloride  <0.014%  <0.014
 Heavy Metals  <20ppm  <20ppm
 Clarity of solution  Conform to standard  Complies
 Microbial Limit  <20ppm  <20ppm
 Assay  >99.0%  99.12%


 
Our Factory and Service:

Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate


How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

Payment and Shipping:

Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate

Packaging:
Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate
Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!
 

Quick Details:
 

Product name: Crizotinib
CAS: 877399-52-5
MF: C21H22Cl2FN5O
MW: 450.343
Purity: 99% min
Appearance: White Crystalline Powder
MOQ:  10 grams
Storage: Store in a cool, dry place
Deliver time: About 5 days 
Deliver methods: By express (door to door)

What is Crizotinib:

Crizotinib (trade name Xalkori,) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy inanaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

How does Crizotinib works:

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK ('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger non-smokers who do not have mutations in either theepidermal growth factor receptor gene (EGFR) or in the K-Ras gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.

Crizotinib is used for:

Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.

Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.

Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.

Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

Do NOT use crizotinib if:

you are allergic to any ingredient in crizotinib
you have previously developed a certain lung problem (pneumonitis) from taking crizotinib
you have a history of certain types of irregular heartbeat (eg, QT prolongation, long QT syndrome)
 
Contact your doctor or health care provider right away if any of these apply to you.

COA:
 
 Test Items  Specification  Results
 Description  White to off white crystalline powder  Comply
 Melting point  166-170ºC  167.3-168.1ºC
 Identification  Positive reaction  Positive reaction
 Related substances  <1.0%  0.16%
 Loss on drying  <0.5%  0.06%
 Residue on ignition  <0.1%  0.02%
 Chloride  <0.014%  <0.014
 Heavy Metals  <20ppm  <20ppm
 Clarity of solution  Conform to standard  Complies
 Microbial Limit  <20ppm  <20ppm
 Assay  >99.0%  99.12%


 
Our Factory and Service:

Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate


How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

Payment and Shipping:

Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate

Packaging:
Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate
Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!
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