Release date: 2006-08-14 PTFE vascular material can carry VEGF gene transfection Recently, Dr. Tao Sifeng, Department of General Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, confirmed for the first time that vascular endothelial growth factor (VEGF) gene carried by polytetrafluoroethylene (PTFE) vascular material, It can transfect endothelial cells implanted on its surface and promote endothelial cell growth.
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According to the study, with the deepening of research on gene therapy for vascular diseases, people began to apply genes to transform artificial blood vessels. However, it is a hot research topic in this field to choose which gene to transfect and how to make the gene can promote the growth of endothelial cells.
In order to break through the bottleneck of this research, Tao Sifeng and other researchers used in vitro experimental research methods to select PTFE as a vascular material carrier, and injected pCé„„DI-hVEGF121 plasmid solution into PTFE artificial blood vessels to make the plasmid enter the pores of artificial blood vessel wall. Next, the endothelial cells isolated from the human umbilical vein were planted on the surface of the PTFE material carrying the VEGF gene plasmid, subcultured at 6, 24, 72 and 120 hours, and the endothelial cells were detected by ELISA. Proliferation and expression of VEGF protein.
The results showed that the adhesion rate of endothelial cells in the VEGF plasmid group was significantly higher than that in the blank control group at 24, 72 and 120 hours (P<0.05). At the same time, with the prolongation of culture time, VEGF gene is continuously transfected into endothelial cells and expresses VEGF. At 120 hours, the proliferation rate of endothelial cells was 4.6 times that of the blank control group, and the concentration of VEGF protein was 539.3 pg/ml, and that of the blank control group was 10.8 pg/ml. There was a significant difference between the two groups. (P<0.01). It is suggested that the VEGF gene carried by PTFE has been successfully transfected into endothelial cells, and the expression of VEGF protein and the rapid proliferation of endothelial cells are achieved.
The researchers believe that VEGF is the strongest and most specific growth factor for inducing vascular endothelial cell growth. PTFE, as a good carrier of artificial vascular material, has its own porous characteristics, which can stabilize the VEGF gene plasmid into its pores. The mechanism of adhesion and release may be: PTFE material is in close contact with endothelial cells, providing space for plasmid transfection of endothelial cells; mixing of fibronectin and gene plasmid improves the compatibility of plasmid and tissue cells by adhesion The endocytosis effect of the molecular receptor and fibrin mediates the coordinated entry of the gene plasmid. This study shows that PTFE vascular materials can carry VEGF gene plasmids and can transfect endothelial cells implanted on the surface of VEGF to promote their rapid growth. This result opens up new prospects for the wide application of PTFE artificial blood vessel materials.
Source: China Medical News
