Ligustrum lucidum anti-osteoporosis mechanism announced

Release date: 2006-10-12

The mechanism of anti-osteoporosis of Ligustrum lucidum was announced. A study completed by Shenyang Pharmaceutical University, State Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology, Hong Kong Polytechnic University and the Chinese University of Hong Kong concluded that the female scorpion passed Improve the sensitivity of the small intestine to active vitamin D and strengthen the renal reabsorption of calcium to improve the calcium imbalance caused by estrogen deficiency. This should be the mechanism for its anti-osteoporosis.
Zhang Yan of Shenyang Pharmaceutical University, who participated in the study, said that postmenopausal osteoporosis in women is usually accompanied by an increase in calcium loss in the body, resulting in a negative calcium balance. With the advent of an aging society, postmenopausal osteoporosis will be one of the most important diseases that threaten human health. The US Food and Drug Administration (FDA) has approved the listing of some chemicals to prevent osteoporosis in postmenopausal women, but recent studies have shown that long-term use of these drugs can bring varying degrees of side effects. As a result, people began to seek safe and effective drugs from a wealth of natural Chinese medicine treasures to prevent and cure the disease. Chinese medicine female scorpion has the function of nourishing liver and kidney, strong waist and knee, attending liver and kidney yin deficiency, dizziness, early white hair, rheumatic pain, waist and knees and so on. Previous studies have shown that Ligustrum lucidum promotes the nourishing function of the endocrine system. The effect of Ligustrum lucidum on calcium metabolism and related vitamin D-dependent gene expression in ovariectomized rats has not been reported. This experiment was conducted to provide theoretical basis for the further research and development of Ligustrum lucidum.
During the experiment, the researchers performed ovariectomy on the experimental rats and administered it for 14 weeks after 4 weeks of operation. The colorimetric method was used to determine the calcium levels in serum, urine and feces to reverse transcriptase-polymerase. Chain reaction (RT-PCR) technique was used to analyze gene expression in the small intestine and kidney. It was found that the calcium loss in the rats after ovariectomy was significantly increased, which was manifested by decreased blood calcium, increased urinary calcium and fecal calcium excretion. Ligustrum lucidum can effectively prevent urinary calcium and fecal calcium excretion and restore blood calcium levels. RT-PCR analysis showed that both estradiol and Ligustrum lucidum could inhibit the expression of vitamin D receptor (VDR) mRNA in the small intestine caused by ovariectomy. Ligustrum lucidum has no significant effect on renal 25-hydroxyvitamin D1-hydroxylase and 25-hydroxyvitamin D24-hydroxylase mRNA, but it can increase renal calcium-binding protein-9k (CaBP-9k) and calcium-binding protein-28k ( Gene expression of CaBP-28k).
The researchers believe that the results of this experiment show that the inhibition of renal calcium excretion by Ligustrum lucidum can be related to the increase of the expression of CaBP-9k and CaBP-28k in the kidney, because the results of this experiment indicate that Ligustrum lucidum can increase the expression of VDR in the small intestine. Intestinal calcium absorption enhances renal calcium reabsorption by upregulating kidney calcium binding protein. In conclusion, Ligustrum lucidum is of great significance for maintaining calcium homeostasis and improving postmenopausal osteoporosis, and it is worthy of further study.
Source: China Medical News

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